Mbappe announced his exit from PSG last week with Real Madrid his expected destination as his deal expires.
Enrique said: "Ours is such a complex sport that the teams that have the best players do not win all their games - we have known this for some time. It doesn't change the general picture.
"All my decisions were made based on what I thought was best for the team. There is still a title to win, this is our goal: regardless of the players, we will be stronger next season. I can only say positive things about Mbapp and his brother.
"I understand his decision, he spent 7 years here, he is a legend of the club. He has given everything for PSG and has not yet said where he will go, even if it is clear. He is a leader, with a smile I wish him the best. I give him 10 as a person and 10 as a footballer."